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DHPLC Columns

At present, there are two competing columns available for DHPLC analysis.

The original column is packed with alkylkated poly(styrene-divinylbenzene) particles.
[Bonn, G., Huber, C., Oefner, P. (1996) Nucleic Acid Separation on Alkylated Nonporous Polymer Beads. U.S. Patent No. 5,585,236].
The material is commercially available from Transgenomic, Inc.

DNASep Column, Part No. 621 5046

Transgenomic, Inc.
2032 Concourse Drive,
San Jose, CA 95131
Phone: (408) 894-9200


Varian also offers a column for DNA analysis and DHPLC. This column is packed with 1000 Å alkylated silica. The Helix column is available in a 3.0 mm ID X 50 mm length, and has the advantage of lower buffer consumption, stronger signal intensity, and five-minute analyses times. The column is generally available and is not restricted to Helix system users.

Helix Analytical Column, Part. No. CP28353

For further information regarding the Helix system or column, please go to the BioSolutions web page at or contact:

Rod Rodman
Phone: (925) 942-2363

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  DHPLC Melt Program


  DHPLC publication lists


  Human genes screened by DHPLC

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browse the lists online or download the complete list of human genes screened by DHPLC including references in pdf format.

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last updated 07/07/2003 | © Stanford Genome Technology Center